LYMPHOID NEOPLASIA IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions
نویسندگان
چکیده
1The Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, NY; 2Department of Haemato-Oncology, King’s College London, London, United Kingdom; 3Department of Medicine, North Shore University Hospital, North Shore–Long Island Jewish Health System, Manhasset, NY; 4Department of Medicine, Hofstra North Shore–Long Island Jewish School of Medicine, Hempstead, NY; 5Department of Medicine, Long Island Jewish Medical Center, North Shore–Long Island Jewish Health System, New Hyde Park, NY; 6Departments of Cell Biology and Medicine, Albert Einstein College of Medicine, Bronx, NY; 7Department of Applied Mathematics and Statistics, State University of New York, Stony Brook, NY; and 8Departments of Molecular Medicine and Medicine, Hofstra North Shore–Long Island Jewish School of Medicine, Hempstead, NY
منابع مشابه
IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.
Clonal evolution occurs during the course of chronic lymphocytic leukemia (CLL) and activation-induced deaminase (AID) could influence this process. However, this possibility has been questioned in CLL because the number of circulating AID mRNA(+) cells is exceedingly low; synthesis of AID protein by blood CLL cells has not been demonstrated; the full range of AID functions is lacking in unmuta...
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