LYMPHOID NEOPLASIA IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions

نویسندگان

  • Piers E. M. Patten
  • Charles C. Chu
  • Emilia Albesiano
  • Rajendra N. Damle
  • Xiao-Jie Yan
  • Dorothy Kim
  • Lu Zhang
  • Amanda R. Magli
  • Jacqueline Barrientos
  • Jonathan E. Kolitz
  • Steven L. Allen
  • Kanti R. Rai
  • Sergio Roa
  • Patricia K. Mongini
  • Thomas MacCarthy
  • Matthew D. Scharff
  • Nicholas Chiorazzi
چکیده

1The Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, NY; 2Department of Haemato-Oncology, King’s College London, London, United Kingdom; 3Department of Medicine, North Shore University Hospital, North Shore–Long Island Jewish Health System, Manhasset, NY; 4Department of Medicine, Hofstra North Shore–Long Island Jewish School of Medicine, Hempstead, NY; 5Department of Medicine, Long Island Jewish Medical Center, North Shore–Long Island Jewish Health System, New Hyde Park, NY; 6Departments of Cell Biology and Medicine, Albert Einstein College of Medicine, Bronx, NY; 7Department of Applied Mathematics and Statistics, State University of New York, Stony Brook, NY; and 8Departments of Molecular Medicine and Medicine, Hofstra North Shore–Long Island Jewish School of Medicine, Hempstead, NY

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.

Clonal evolution occurs during the course of chronic lymphocytic leukemia (CLL) and activation-induced deaminase (AID) could influence this process. However, this possibility has been questioned in CLL because the number of circulating AID mRNA(+) cells is exceedingly low; synthesis of AID protein by blood CLL cells has not been demonstrated; the full range of AID functions is lacking in unmuta...

متن کامل

Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia

Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as a novel interaction partner of ROR1. COBLL1 shows clear bimodal expression with high levels in chronic lymphocytic leukemia patients with mutated IGHV and approximately 30% of chronic ly...

متن کامل

Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells

The immunoglobulin heavy-chain variable region (IGHV) mutational status is a strong determinant of remission duration in chronic lymphocytic leukemia (CLL). The aim of this work was to compare the multidrug resistance (MDR) signature of IGHV mutated and unmutated CLL cells, identifying biochemical and molecular targets potentially amenable to therapeutic intervention.We found that the mevalonat...

متن کامل

Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution

Patients with chromosome 13q deletion or normal cytogenetics represent the majority of chronic lymphocytic leukaemia (CLL) cases, yet have relatively few driver mutations. To better understand their genomic landscape, here we perform whole-genome sequencing on a cohort of patients enriched with these cytogenetic characteristics. Mutations in known CLL drivers are seen in only 33% of this cohort...

متن کامل

Preferential use of unmutated immunoglobulin heavy variable region genes in Boxer dogs with chronic lymphocytic leukemia

Human chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease, and immunoglobulin heavy variable region (IGHV) gene mutational status is an important prognostic marker. IGHV mutational status has not been previously examined in canine CLL. We sequenced the IGHV-D-J rearrangements from 55 canine patients with CLL, including 36 non-Boxer and 19 Boxer dogs. The majority of non-Box...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012